Author(s): Philip Ball

Nature | Evolution

A cutting-edge new vision of biology that will revise our concept of what life itself is, how to enhance it, and what possibilities it offers.

Biology is undergoing a quiet but profound transformation. Several aspects of the standard picture of how life works—the idea of the genome as a blueprint, of genes as instructions for building an organism, of proteins as precisely tailored molecular machines, of cells as entities with fixed identities, and more—have been exposed as incomplete, misleading, or wrong.

In How Life Works, Philip Ball explores the new biology, revealing life to be a far richer, more ingenious affair than we had guessed. Ball explains that there is no unique place to look for an answer to this question: life is a system of many levels—genes, proteins, cells, tissues, and body modules such as the immune system and the nervous system—each with its own rules and principles. How Life Works explains how these levels operate, interface, and work together (most of the time). With this knowledge come new possibilities.

Today we can redesign and reconfigure living systems, tissues, and organisms. We can reprogram cells, for instance, to carry out new tasks and grow into structures not seen in the natural world. As we discover the conditions that dictate the forms into which cells organize themselves, our ability to guide and select the outcomes becomes ever more extraordinary.

Some researchers believe that ultimately we will be able to regenerate limbs and organs, and perhaps even create new life forms that evolution has never imagined.

Incorporating the latest research and insights, How Life Works is a sweeping journey into this new frontier of the life sciences, a realm that will reshape our understanding of life as we know it.

Review: Ball's marvelous book is both wide-ranging and deep . . . How Life Works has exciting implications for the future of the science of biology itself. I could not put it down. -- Siddhartha Mukherjee, author of The Emperor of All Maladies, winner of the Pulitzer Prize for Non-Fiction
Ball takes glee in tearing down scientific shibboleths . . . and his penetrating analysis underscores the stakes of outdated assumptions. . . . Provocative and profound, this has the power to change how readers understand life's most basic mechanisms. * Publishers Weekly *
Ball has the rare ability to explain scientific concepts across very diverse disciplines. . . . He explains the turn away from a purely mechanical view of life to one that embraces the inherently dynamic, complex, multilayered, interactive, and cognitive nature of the processes by which life sustains and regenerates itself. -- James Shapiro, author of Evolution
Offers a much-needed examination of exciting, cutting-edge findings in contemporary biology that is likely to dramatically transform our understanding of living systems -- Daniel J. Nicholson, coeditor of Everything Flows
In showing that complex life is more 'emergent' than 'programmed,' Ball takes on many conventional notions about biology. 'We are at the beginning of a profound rethinking of how life works,' he writes. Evolution has consistently invented new ways of creating living beings, and it will continue to do so. 'The challenge,' writes the author, 'is to find a good way of talking about these vital stratagems,' and his latest book offers plenty of food for thought for scientists in disciplines from medicine to engineering. A bold effort to create a new language that forces a 'rethinking' of 'thinking itself.' * Kirkus Reviews, starred review *

Author Biography: Philip Ball is a freelance writer and broadcaster, and was an editor at Nature for more than twenty years. He writes regularly in the scientific and popular media and has written many books on the interactions of the sciences, the arts, and wider culture. His book Critical Mass won the 2005 Aventis Prize for Science Books. Ball is also a presenter of Science Stories, the BBC Radio 4 series on the history of science. He trained as a chemist at the University of Oxford and as a physicist at the University of Bristol. He is the author of The Modern Myths, The Book of Minds, and How Life Works. He lives in London.